What is Bioidentical Progesterone
Progesterone is a naturally occurring and bioidentical progestogen, or an agonist of the progesterone receptor, the biological target of progestogens like endogenous progesterone. Progesterone also has antimineralocorticoid and inhibitory neurosteroid activity, whereas it appears to have little or no glucocorticoid or antiandrogenic activity and has no androgenic activity. Because of its progestogenic activity, progesterone has functional antiestrogenic effects in certain tissues such as the uterus, cervix, and vagina. In addition, progesterone has antigonadotropic effects due to its progestogenic activity and can inhibit fertility and suppress sex hormone production. Progesterone differs from progestins (synthetic progestogens) like medroxyprogesterone acetate and norethisterone, with implications for pharmacodynamics and pharmacokinetics as well as efficacy, tolerability, and safety.[17]
Progesterone is used as part of hormone replacement therapy in people who have low progesterone levels, and for other reasons. Routes of administration that progesterone has been used include oral, intranasal, sublingual, transdermal, vaginal, rectal, intramuscular, subcutaneous, and intravenous injection
How does Progesterone work
- Cognitive function
- Mood and anxiety
- Sleep
- Energy
- Balances excess Estrogen
- Reduces inflammation an pain
- Supports adrenal function
- Supports during the peri-menopause, menopause and post-menopause phases
- Used in treatment for epilepsy, brain injury and brain trauma
Sources
After a thorough research, sharing below few links that I found helpful
Links for Research
- Dr Ray Peat – Progesterone Pregnenolone & DHEA – Three Youth-Associated Hormones
- Dr. Katharina Dalton – the PMS Doctor
- Dr. Ray Peat – Aging, estrogen, and progesterone
- Readings of Dr Ray Peat’s work by Jared Pitts
- 5 Hormone Related Causes of Anxiety in Women
- Progesterone vs. synthetic progestins and the risk of breast cancer: a systematic review and meta-analysis
- Progesterone therapy in women with epilepsy
- Beyond the HPA axis: progesterone-derived neuroactive steroids in human stress and emotion
- Cognition, Mood and Sleep in Menopausal Transition: The Role of Menopause Hormone Therapy
- Diagnostic and therapeutic use of oral micronized progesterone in endocrinology
- Why Breaking Up Your Progesterone Dose Can be Better
- Progesterone (or pregnenolone) – a cheap, safe and effective treatment of infertility
- Low progesterone, not low estrogen, drives night sweats, insomnia of menopause
- Why Breaking Up Your Progesterone Dose Can Make All the Difference
Reputed Brands
- Onas Natural : available in various countries
- Long Natural Health
- Health Natura
- Life Blud
